4 ms·
The paper is open access https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6 https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6 It's not "playin
by seydor 3y ago
The paper is open access https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6 https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6
It's not "playing well". The experiment is set up so as to reinforce (through LTP) its dynamics when it performs correct rather than wrong. This ends up "wobbling the paddle around" with a statistically significant better performance than untrained . This is not a brain that knows what it's doing, but a few thousand neurons apparently able to undergo plasticity
- bhaney 3y ago> a few thousand neurons Does that come from somewhere in the paper? I'm seeing "10^6 cells plated onto each MEA" and trying to determine if that's the size of each "DishBrain" or if the number is pared down before actual tests are carried out.
- seydor 3y agoI see in the paper that they used 800K and 1M culture neurons . The device in question however (MaxOne) has a size of 8 square mm. I m not sure if the cells they plated can actually be recorded/ stimulated as the device is rather high resolution with 26400 densely packed electodes that can record from multiple spots of a single neuron. In typical recordings from these there are much fewer neurons in culture
- dr_dshiv 3y agoHow does it reinforce and produce LTP?
- seydor 3y agoIt isn't clear what makes their reward signal predictable but 10 pulses at 100hz looks like an ltp inducing stimulus