Proper sanitizer - e.g. alcohol with ~70% concentration - is as close to "resistance-proof" as is possible. There's never been any indication of adaptations at

Proper sanitizer - e.g. alcohol with ~70% concentration - is as close to "resistance-proof" as is possible. There's never been any indication of adaptations at that level, it's just too destructive to bacterial cells. Avoid the "alcohol-free" sanitizers since they rely on other chemicals to achieve the same effect but go crazy with the alcohol-based ones.