3 ms·

Is it possible to blind test this? Like can people feel whether or not the current is passing through their brain? Feels like it should be easy enough to do a s

• swader999 3y ago
  Yes, you can feel the current at times. It is pretty mild though.
• mattkrause 3y ago
  Yes! I ran an experiment where we blocked the skin sensations with topical anesthesia and then recorded the responses of individual neurons to tES. Nothing changed, so the sensation is not necessary for its effects. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000834 https://journals.plos.org/plosbiology/article?id=10.1371/jou... We also created the same sensations elsewhere on the scalp, and this was not sufficient to cause neural entrainment either. https://www.pnas.org/doi/10.1073/pnas.1815958116 https://www.pnas.org/doi/10.1073/pnas.1815958116 Placebo/skin effects can certainly mess up a readout based on performance or behavior but they aren’t the full story either.