4 ms·

Sounds like something you should bring up with your doctor. The only thing I've ever seen is a link between specifically MK7 (currently only sourced from Natto

Sounds like something you should bring up with your doctor. The only thing I've ever seen is a link between specifically MK7 (currently only sourced from Natto; MK4 is what you normally see in all other fermented foods and the majority of K2 supplements; MK7 supplements are very expensive comparatively) combined with large doses of flavonoids (often found in Vitamin C complexes). I have not seen this mentioned in a study, but I suspect the combination of both may be an issue for a minority of people. Lowering the dose or switching to a more conventional MK4 lowered their BP back to normal. As with any supplementation, no matter how innocent, always keep a Doctor handy to run labs: the difference between screwing around and science is keeping notes. That said, studies like https://journals.lww.com/md-journal/Fulltext/2021/06110/Vitamin_K2__Menaquinone_7__supplementation_does.29.aspx https://journals.lww.com/md-journal/Fulltext/2021/06110/Vita... and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230802/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230802/ seem to indicate that even MK7, as opposed to just MK4, should be strongly considered for inclusion in the common multivitamin.

arthur2e5 3y ago
The K1/K2 taxonomy is… not great, precisely because MK-4 and MK-7 can work quite differently. There are also forms of K not falling into either category, because microbes love to partitially hydrogenate the chain leaving you weird in-betweens.
- DiabloD3 3y ago
  Yeah, I agree. Also doesn't help education of the public due to all the weird forms. It isn't as bad as how the B complex works; a bunch of different vitamins who keep appearing next to each other in numerous reactions.
  - arthur2e5 3y ago
    There's also the fun little dude called K3. Started as a cheapo synthetic form that causes oxidative liver damage in high doses, turns out your body makes it too when you take other forms of K -- it could be what the body uses to ship Vitamin K pass the blood-brain barrier, but nobody's sure. The damage is still true though. Natural != good, especially when you screw with doses. * * * Oh, B. When all the other subscripts are for Vitamers, there's this one guy that just wants to be different. It's not like we don't have enough letters! Having some similarities does not justify this terrible nomenclature!

arthur2e5 3y ago

The K1/K2 taxonomy is… not great, precisely because MK-4 and MK-7 can work quite differently. There are also forms of K not falling into either category, because microbes love to partitially hydrogenate the chain leaving you weird in-betweens.

DiabloD3 3y ago
Yeah, I agree. Also doesn't help education of the public due to all the weird forms. It isn't as bad as how the B complex works; a bunch of different vitamins who keep appearing next to each other in numerous reactions.
- arthur2e5 3y ago
  There's also the fun little dude called K3. Started as a cheapo synthetic form that causes oxidative liver damage in high doses, turns out your body makes it too when you take other forms of K -- it could be what the body uses to ship Vitamin K pass the blood-brain barrier, but nobody's sure. The damage is still true though. Natural != good, especially when you screw with doses. * * * Oh, B. When all the other subscripts are for Vitamers, there's this one guy that just wants to be different. It's not like we don't have enough letters! Having some similarities does not justify this terrible nomenclature!