Considering that most production in space (with even near future launch costs) would mainly only be worthwhile if the resources were also obtained from space, I

Considering that most production in space (with even near future launch costs) would mainly only be worthwhile if the resources were also obtained from space, I don't think radiation shielding will be as much of an issue, since if you're doing ISRU, you can gather enough mass around the facility to handle shielding. For chip fab in particular, since current processes require a lot of water, and water is very good as radiation shielding, such a facility in space would probably just store water in the walls.