3 ms·
Covid-19 vaccination can induce MS via cross-reactive CD4T cells
- anonymouskimmer 3y agoAs can SARS-CoV-2 infection: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340057/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340057/ > We report a first presentation of CNS demyelinating disease shortly after COVID-19 disease. To date, there is little evidence previously described in the literature (Zanin et al., 2020). In our case, the patient presented symptoms attributed to COVID-19 infection (anosmia and dysgeusia) prior to the visual manifestations. The brief temporal gap leads us to consider the existence of a causal relationship. > There is plenty of evidence to support the association between viral infections and the development of demyelinating diseases. For example, Epstein-Barr virus infection is considered an important risk factor for the development of multiple sclerosis (Donati, 2020). Other viruses that cause common infections in humans like varicella-zoster, influenza or adenovirus are associated with more frequent and severe relapses in patients with MS (Andersen et al., 1993; McKay et al., 2017). Indeed, some studies show that viral respiratory tract infections may be linked to most of the exacerbations of MS (Marrodan et al., 2019). Or make it worse: https://pubmed.ncbi.nlm.nih.gov/34010764/ https://pubmed.ncbi.nlm.nih.gov/34010764/ If you, and those who live with you, take significant precautions to avoid infection, then you're gold. You don't need to get infected or vaccinated. It's always better to not get infected in the first place. Only if you can't take these precautions do you have to weigh the risks/benefits of vaccination versus infection. Hopefully these results will allow better design of vaccines to eliminate the parts of the spike protein that generate cross-reactive antibodies.