3 ms·
I had to log in because you're ignorant, and your dismissal takes far less effort than proving my side. From "Emerging Perspectives on the Antiparasitic Mebend
by davisr 3y ago
I had to log in because you're ignorant, and your dismissal takes far less effort than proving my side.
From "Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers", 2023:
> Mebendazole can penetrate the blood-brain barrier and has been shown to inhibit the malignant progression of glioma by targeting signaling pathways related to cell proliferation, apoptosis, or invasion/migration, or by increasing the sensitivity of glioma cells to conventional chemotherapy or radiotherapy.
https://pubmed.ncbi.nlm.nih.gov/36674870/ https://pubmed.ncbi.nlm.nih.gov/36674870/
From "Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme", 2011:
> Our findings indicate that mebendazole is a possible novel anti-brain tumor therapeutic that could be further tested in clinical trials.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158014/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158014/
"Surprise Finding Yields a Possible Tumor-Fighting Drug", 2014:
> Searching the literature, they found reports that fenbendazole had been shown to inhibit cancer growth. Then, by trial and error, they determined that the related drug mebendazole—which has been used for the last 60 years to treat parasites in the human gastrointestinal tract—might also hold potential for stalling glioblastoma.
https://www.cancer.columbia.edu/news/promising-treatment-deadly-brain-cancer https://www.cancer.columbia.edu/news/promising-treatment-dea...
And, you _do_ hear of people using these antihelmintics, in conjunction with conventional cancer therapies, for treating their disease. There is a large community on Reddit around the Joe Tippens protocol, who has never been disproved.
> His next sentence almost floored me. He said, "You know, we’ve known for decades that these anthelmintic class of drugs (meaning to destroy parasites in the intestines) could have possible efficacy against cancer, and in fact in the 80's and 90's there was a drug called Levamisole that was used on colon cancer and it is an anthelmintic drug".
> I said, "Doc, if you have known for decades why hasn’t more work been done on it?" His answer was honest. He said, "probably because of money…all of these drugs are far off-patent and nobody is going to spend a gazillion dollars to repurpose them for cancer...only to have generic competition the next day."
https://mycancerstory.rocks/the-blog/ https://mycancerstory.rocks/the-blog/
See also: "Repurposing Drugs to Fight Cancer", 2020
https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs-cancer.html https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs...