4 ms·

Mebendazole and fenbendazole, antihelmintics, have also shown effective against gioblastoma and other types of cancer. Mebendazole, and others in its family, a

by davisr 3y ago

Mebendazole and fenbendazole, antihelmintics, have also shown effective against gioblastoma and other types of cancer. Mebendazole, and others in its family, are also involved in a broken healthcare system in the US, where these medications costs between $0.07 and $10.00 per tablet in every other country, but there is a monopoly on manufacture that can price these tablets at $350 per tablet.

JPLeRouzic 3y ago
$6.52 in Belgium: https://www.pharmachezvous.be/medicaments/vermifuge/vermox-comp-6x100mg-2/ https://www.pharmachezvous.be/medicaments/vermifuge/vermox-c...
meindnoch 3y ago
Surely, if glioblastoma (the most aggressive form of brain cancer) could be cured with such simple anti-parasite medications, we'd be hearing about people curing themselves... This sounds like covid-19 and ivermectin.
- ekianjo 3y ago
  Dont underestimate the level of corruption in the existing system
  - _Microft 3y ago
    They said that people would experiment with these drugs on themselves to cure their cancer (assuming that these drugs were actually as effective as claimed). There seems no obvious system involved in this. Which system do you mean?
    - davisr 3y ago
      The system that won't spend millions of dollars to repurpose (and re-certify) generic drugs with the FDA...drugs that already have off-label uses for treating cancer. https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs-cancer.html https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs...
- davisr 3y ago
  I had to log in because you're ignorant, and your dismissal takes far less effort than proving my side. From "Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers", 2023: > Mebendazole can penetrate the blood-brain barrier and has been shown to inhibit the malignant progression of glioma by targeting signaling pathways related to cell proliferation, apoptosis, or invasion/migration, or by increasing the sensitivity of glioma cells to conventional chemotherapy or radiotherapy. https://pubmed.ncbi.nlm.nih.gov/36674870/ https://pubmed.ncbi.nlm.nih.gov/36674870/ From "Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme", 2011: > Our findings indicate that mebendazole is a possible novel anti-brain tumor therapeutic that could be further tested in clinical trials. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158014/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158014/ "Surprise Finding Yields a Possible Tumor-Fighting Drug", 2014: > Searching the literature, they found reports that fenbendazole had been shown to inhibit cancer growth. Then, by trial and error, they determined that the related drug mebendazole—which has been used for the last 60 years to treat parasites in the human gastrointestinal tract—might also hold potential for stalling glioblastoma. https://www.cancer.columbia.edu/news/promising-treatment-deadly-brain-cancer https://www.cancer.columbia.edu/news/promising-treatment-dea... And, you _do_ hear of people using these antihelmintics, in conjunction with conventional cancer therapies, for treating their disease. There is a large community on Reddit around the Joe Tippens protocol, who has never been disproved. > His next sentence almost floored me. He said, "You know, we’ve known for decades that these anthelmintic class of drugs (meaning to destroy parasites in the intestines) could have possible efficacy against cancer, and in fact in the 80's and 90's there was a drug called Levamisole that was used on colon cancer and it is an anthelmintic drug". > I said, "Doc, if you have known for decades why hasn’t more work been done on it?" His answer was honest. He said, "probably because of money…all of these drugs are far off-patent and nobody is going to spend a gazillion dollars to repurpose them for cancer...only to have generic competition the next day." https://mycancerstory.rocks/the-blog/ https://mycancerstory.rocks/the-blog/ See also: "Repurposing Drugs to Fight Cancer", 2020 https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs-cancer.html https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs...

by davisr 3y ago

JPLeRouzic 3y ago

$6.52 in Belgium: https://www.pharmachezvous.be/medicaments/vermifuge/vermox-comp-6x100mg-2/ https://www.pharmachezvous.be/medicaments/vermifuge/vermox-c...

meindnoch 3y ago

Surely, if glioblastoma (the most aggressive form of brain cancer) could be cured with such simple anti-parasite medications, we'd be hearing about people curing themselves... This sounds like covid-19 and ivermectin.

ekianjo 3y ago
Dont underestimate the level of corruption in the existing system
- _Microft 3y ago
  They said that people would experiment with these drugs on themselves to cure their cancer (assuming that these drugs were actually as effective as claimed). There seems no obvious system involved in this. Which system do you mean?
  - davisr 3y ago
    The system that won't spend millions of dollars to repurpose (and re-certify) generic drugs with the FDA...drugs that already have off-label uses for treating cancer. https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs-cancer.html https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs...
davisr 3y ago
I had to log in because you're ignorant, and your dismissal takes far less effort than proving my side. From "Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers", 2023: > Mebendazole can penetrate the blood-brain barrier and has been shown to inhibit the malignant progression of glioma by targeting signaling pathways related to cell proliferation, apoptosis, or invasion/migration, or by increasing the sensitivity of glioma cells to conventional chemotherapy or radiotherapy. https://pubmed.ncbi.nlm.nih.gov/36674870/ https://pubmed.ncbi.nlm.nih.gov/36674870/ From "Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme", 2011: > Our findings indicate that mebendazole is a possible novel anti-brain tumor therapeutic that could be further tested in clinical trials. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158014/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158014/ "Surprise Finding Yields a Possible Tumor-Fighting Drug", 2014: > Searching the literature, they found reports that fenbendazole had been shown to inhibit cancer growth. Then, by trial and error, they determined that the related drug mebendazole—which has been used for the last 60 years to treat parasites in the human gastrointestinal tract—might also hold potential for stalling glioblastoma. https://www.cancer.columbia.edu/news/promising-treatment-deadly-brain-cancer https://www.cancer.columbia.edu/news/promising-treatment-dea... And, you _do_ hear of people using these antihelmintics, in conjunction with conventional cancer therapies, for treating their disease. There is a large community on Reddit around the Joe Tippens protocol, who has never been disproved. > His next sentence almost floored me. He said, "You know, we’ve known for decades that these anthelmintic class of drugs (meaning to destroy parasites in the intestines) could have possible efficacy against cancer, and in fact in the 80's and 90's there was a drug called Levamisole that was used on colon cancer and it is an anthelmintic drug". > I said, "Doc, if you have known for decades why hasn’t more work been done on it?" His answer was honest. He said, "probably because of money…all of these drugs are far off-patent and nobody is going to spend a gazillion dollars to repurpose them for cancer...only to have generic competition the next day." https://mycancerstory.rocks/the-blog/ https://mycancerstory.rocks/the-blog/ See also: "Repurposing Drugs to Fight Cancer", 2020 https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs-cancer.html https://www.nytimes.com/2020/02/25/opinion/repurposing-drugs...