I'm half-assedly pulling this out of recollection. I believe nucleic-acid based vaccines prompt a greater response from the part of the adaptive immune system t

I'm half-assedly pulling this out of recollection. I believe nucleic-acid based vaccines prompt a greater response from the part of the adaptive immune system that is not the antibody part, while protein-based vaccines preferentially boost the antibody response. They do this because the antigen is expressed within the cell.