We have decades of partial answers as to how the brain affects the gut, but none are anywhere near complete. This finding, that some gluco-corticoid derivative

We have decades of partial answers as to how the brain affects the gut, but none are anywhere near complete. This finding, that some gluco-corticoid derivatives inhibit cell maturation, is new in its specifics but there was plenty of evidence to suggest the hypothesis. But it's a tiny part of an entire ecosystem. People are already told to avoid NSAID's, so it will have little clinical impact. Saying "autoimmune disease" is as precise as saying you have a performance problem in the cloud. Worse, people mistakenly use that term for any chronic immune-system-mediated syndrome. Even worse, saying that "People are sick because society is stressed, so we should reduce stress in society" completely misdirects useful resources. People who want to do good need to dig in and do the work, not hand-wave. Chronic immune-mediated diseases fall in the crack between primary care and GI specialists. The specialists only have time for surgery or drugs, and primary care doesn't have the expertise for the patient months-long self-experiments required to isolate relevant factors (among diet, stress, infectious disease, microbiome, genetics). This is a structural health-care opportunity for anyone able to take it. Private equity could fund practice groups with a few doctors and 6:1 advanced-practice providers, partnered with diagnostics and EHR peers, carefully working through and evolving GI algorithms and diagnostics. The alternatives (surgery and drugs) are expensive and ineffective and the incidence is high, so the market is definitely worth pursuing. Longer-term, it may help with automating the actual practice of medicine, where each patient is an experiment with a series of knowns, some negotiated interventions, and a track record of results: all invaluable data for this case and those like it, and a methodology applicable to other chronic immune diseases. Automating the accumulation of expertise scientifically in a practice system is really the future of computers in medicine. It will never happen via diagnostics (Quest, LabCorps) or EHR (Cerner/Epic) because their virtues are contra-indicated in the continuous experiment of treating chronic disease.