4 ms·

There's a lot of research into ways to treat C. difficile. Some of it is genuinely antimicrobial stewardship - keeping people off proton pump inhibitors and ce

by Fomite 3y ago

There's a lot of research into ways to treat C. difficile. Some of it is genuinely antimicrobial stewardship - keeping people off proton pump inhibitors and certain classes of antibiotics. Fecal transplant is also getting both more viable and better understood (this is what I worked on for my dissertation). There's also some investigation of alternative therapeutics for C. diff that aren't just vancomycin.

71a54xd 3y ago
Interesting to hear from someone who's studied this professionally. Fortunately a drug that was recently in clinical trials as RBX 2660 [0] was recently approved for use within the US as REBYOTA [1]. It's an improved engineered version of a fecal transplant. It's actually free even if you don't have insurance although, you have to have two recorded recurrences of Cdiff to be approved. Vancomycin is incredibly expensive, one course WITH insurance was around $385. I've found a few brands of probiotics work well for maintenance as my recovery continues with some clinically supported probiotics and a diet that avoids trigger foods / too much sugar. BioGaia [2] - contains L. reuteri which is clinically shown to combat active cdiff Florastore [3] - creates a biofilm that aids in removing cdiff spores from your gut BioK + [4] (intended to be used in conjunction with antibiotics to help avoid cdiff / has variants used for patients with feeding tubes to maintain gut health) At this point, I'm back to being healthy and gaining weight, hoping I don't have serious colon cancer risk factors in the future. Curiously, for those who don't know, (I didn't) when you take Vancomycin you're supposed to suppress calcium intake as much as possible AND avoid any and all trigger foods for gut inflamation. 0 - https://pubmed.ncbi.nlm.nih.gov/36287379/ https://pubmed.ncbi.nlm.nih.gov/36287379/ 1 - https://ferringusa.com/?press=ferring-receives-u-s-fda-approval-for-rebyota-fecal-microbiota-live-jslm-a-novel-first-in-class-microbiota-based-live-biotherapeutic https://ferringusa.com/?press=ferring-receives-u-s-fda-appro... 2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607411/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607411/ 3 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805518/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805518/ 4 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291414/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291414/

by Fomite 3y ago

71a54xd 3y ago

Interesting to hear from someone who's studied this professionally. Fortunately a drug that was recently in clinical trials as RBX 2660 [0] was recently approved for use within the US as REBYOTA [1]. It's an improved engineered version of a fecal transplant. It's actually free even if you don't have insurance although, you have to have two recorded recurrences of Cdiff to be approved. Vancomycin is incredibly expensive, one course WITH insurance was around $385. I've found a few brands of probiotics work well for maintenance as my recovery continues with some clinically supported probiotics and a diet that avoids trigger foods / too much sugar. BioGaia [2] - contains L. reuteri which is clinically shown to combat active cdiff Florastore [3] - creates a biofilm that aids in removing cdiff spores from your gut BioK + [4] (intended to be used in conjunction with antibiotics to help avoid cdiff / has variants used for patients with feeding tubes to maintain gut health) At this point, I'm back to being healthy and gaining weight, hoping I don't have serious colon cancer risk factors in the future. Curiously, for those who don't know, (I didn't) when you take Vancomycin you're supposed to suppress calcium intake as much as possible AND avoid any and all trigger foods for gut inflamation. 0 - https://pubmed.ncbi.nlm.nih.gov/36287379/ https://pubmed.ncbi.nlm.nih.gov/36287379/ 1 - https://ferringusa.com/?press=ferring-receives-u-s-fda-approval-for-rebyota-fecal-microbiota-live-jslm-a-novel-first-in-class-microbiota-based-live-biotherapeutic https://ferringusa.com/?press=ferring-receives-u-s-fda-appro... 2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607411/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607411/ 3 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805518/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805518/ 4 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291414/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291414/