HIGHLIGHTS * The physical aspects of epilepsy are often overlooked. * To gain a deeper comprehension of the underlying mechanism, understanding the involvemen

HIGHLIGHTS * The physical aspects of epilepsy are often overlooked. * To gain a deeper comprehension of the underlying mechanism, understanding the involvement of the physical aspects is crucial. * The relation between epilepsy and pressure, volume, and heat introduces a consistent framework. * In conjunction with certain theoretical works, it is possible to establish a unifying and coherent framework for epilepsy