Full disclosure: I am not an active researcher and haven't been in a wet lab in a while. Not disagreeing with your statement. IMO Cryo-EM is a huge step above

Full disclosure: I am not an active researcher and haven't been in a wet lab in a while. Not disagreeing with your statement. IMO Cryo-EM is a huge step above crystallography and captures way more biologically accurate structures on top of being way easier to do. To get a bit more nuanced: I think there's still a significant gap between the captured structure and biological action, and often people believe that the structure is the be-all and end-all to these conclusions. A simple example would be the location of water molecules and how the hydrogen bonds interact with protein active sites. In many cases it's not hard to impute, but it can be tricky and often requires outside techniques. I think the long term solution would be to directly capture structure level precision in motion, similar to looking at a slide from a mouse model or something. AFAIK we're not there yet, even though we can get pretty close by stitching together captured structures with predictive chemistry models.