>I'm not terribly surprised that ketamine may not produce strong antidepressant effects if the patient is not conscious. That's incorrect, it actually produced

>I'm not terribly surprised that ketamine may not produce strong antidepressant effects if the patient is not conscious. That's incorrect, it actually produced larger antidepressant effects (50% response rate and 40% remission [1]) than when the patient is conscious (40% response rate and 30% remission according to a large meta-analysis [2]). [1] https://www.medrxiv.org/content/10.1101/2023.04.28.23289210v1.full-text https://www.medrxiv.org/content/10.1101/2023.04.28.23289210v... [2] https://pubmed.ncbi.nlm.nih.gov/35688035/ https://pubmed.ncbi.nlm.nih.gov/35688035/ But that large response had nothing to do with ketamine, as the non-ketamine group had the same or higher response.