10 ms·
Peter Attia made a video recently using precisely that observation as the reason he avoids prescribing it except as a last resort, and only then when he can get
by sn9 3y ago
Peter Attia made a video recently using precisely that observation as the reason he avoids prescribing it except as a last resort, and only then when he can get patients to increase their protein intake and start strength training while getting a DEXA before and after to keep track of the relative changes in body fat percentage.
The problem is apparently that studies only use change in weight instead of body composition, so doctors have to be aware of that and get the patient measured themselves to make sure they're actually getting leaner instead of losing weight but getting "more obese".
- reaperman 3y ago> The problem is apparently that studies only use change in weight instead of body composition Misinformation. Many of the studies track total fat, lean body mass, visceral fat, and literally dozens of other secondary outcomes/endpoints. See an example of such results here: https://clinicaltrials.gov/ct2/show/results/NCT03548935 https://clinicaltrials.gov/ct2/show/results/NCT03548935 This has already been covered yesterday in sibling comments about the NCT03548935 study and Peter Attia being in general a source of misinformation. Here are some other semaglutide studies which track lean body mass specifically: https://clinicaltrials.gov/ct2/results?cond=Semaglutide&term=lean+body+mass&cntry=&state=&city=&dist=&Search=Search https://clinicaltrials.gov/ct2/results?cond=Semaglutide&term...