Thanks for the info :) Regarding leaving stuff out. I'm really not. My only concern here is getting my wife well, and she absolutely had none of these symptoms

Thanks for the info :) Regarding leaving stuff out. I'm really not. My only concern here is getting my wife well, and she absolutely had none of these symptoms previously, or any hint of them, and whilst I haven't described every individual visit to ER in detail, they all follow the same pattern as recounted. We've just had the first round of specialists, and I don't have a very high opinion of her PCP, but now that we have the specialists, I'm more hopeful that something might get done. None of the doctors involved told us about the dangers of raising Sodium quickly. The neurologist agreed that it might be and put my wife on Prednisone/something-to-help-her-stomach after our first visit. It was actually my boss' wife (she's a doctor) that mentioned ODS to him and hence to us. FWIW, work has been outstandingly supportive over the last couple of months, the only real shining light. The MRI doesn't seem to support ODS though, but I personally think it's too much of a coincidence that she responded so poorly, and then symptoms very similar to it emerged later. It might not be ODS, but something happened. She had none of these symptoms before going in. As for why she had hyponatremia, she had diarrhoea the week previously, and the hospital put it down to that. We had no idea her sodium was low - as I said we went in for something unrelated (that turned out to be benign). The PCP put her on Ativan, right up until she said "I don't feel comfortable prescribing this any more, so I'm not going to". Cue the argument about withdrawal and the PCP saying she'd talk to the neurologist and see if the neurologist would take over. I get the feeling the PCP is very much a "fair weather" doctor - fine for when things are fine... The neurologist has changed away from Ativan to another benzo, but has also prescribed mirtazapine as a more long-term solution. We have another visit with her scheduled at the end of the month.