6 ms·

> The manual for Alli makes it clear that orlistat treatment involves aversion therapy, encouraging the user to associate eating fat with unpleasant treatment e

> The manual for Alli makes it clear that orlistat treatment involves aversion therapy, encouraging the user to associate eating fat with unpleasant treatment effects. Christ. This is like Crohn's disease in pill form. One too many teaspoons of olive oil and you're in for an unpleasant evening...

ortusdux 3y ago
I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.
- op00to 3y ago
  [flagged]
  - aidenn0 3y ago
    I want to frame this comment as an example of (the generalized form of) Poe's law.
    - op00to 3y ago
      It’s better to not know.
- znpy 3y ago
  Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up. Does the fda allow that?
  - stavros 3y ago
    Yes, why would the FDA restrict what color pants you wear?
  - Retric 3y ago
    There’s huge tradeoffs people rarely talk about in Medicine. Significant risk of soiling yourself vs a statistically significant reduction in risk of early death isn’t a big deal for the FDA. In many cases the hell that is chemo is considered acceptable for even moderate increases in expected lifespan. That’s why people started talking healthy life expectancy vs just life expectancy.
    - AtlasBarfed 3y ago
      Well duh, if you discuss the side effects with patients, they won't take the drug and the drug people won't send you hookers.
      - lazyasciiart 3y ago
        Bizarrely enough, the pressure doesn't always go in that direction.
reaperman 3y ago
I don't have a colon (but I do still have a functioning anus). The effects from orlistat are very similar to what I experience 24/7. If you're under 30 or so, eventually your sphincter gets much, much stronger and the excess oil stops affecting you nearly as much. You can hold it in indefinitely until your normal "need to go" timing. This takes about a year or so to train, and you'll have quite a few accidents in the meantime. I still can't eat too much salmon in one sitting though :-( I don't get diarrhea but I do get stuck on the toilet for ages after.

ortusdux 3y ago

I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.

op00to 3y ago
[flagged]
- aidenn0 3y ago
  I want to frame this comment as an example of (the generalized form of) Poe's law.
  - op00to 3y ago
    It’s better to not know.
znpy 3y ago
Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up. Does the fda allow that?
- stavros 3y ago
  Yes, why would the FDA restrict what color pants you wear?
- Retric 3y ago
  There’s huge tradeoffs people rarely talk about in Medicine. Significant risk of soiling yourself vs a statistically significant reduction in risk of early death isn’t a big deal for the FDA. In many cases the hell that is chemo is considered acceptable for even moderate increases in expected lifespan. That’s why people started talking healthy life expectancy vs just life expectancy.
  - AtlasBarfed 3y ago
    Well duh, if you discuss the side effects with patients, they won't take the drug and the drug people won't send you hookers.
    - lazyasciiart 3y ago
      Bizarrely enough, the pressure doesn't always go in that direction.

reaperman 3y ago

I don't have a colon (but I do still have a functioning anus). The effects from orlistat are very similar to what I experience 24/7. If you're under 30 or so, eventually your sphincter gets much, much stronger and the excess oil stops affecting you nearly as much. You can hold it in indefinitely until your normal "need to go" timing. This takes about a year or so to train, and you'll have quite a few accidents in the meantime. I still can't eat too much salmon in one sitting though :-( I don't get diarrhea but I do get stuck on the toilet for ages after.