5 ms·

>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes

>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat. https://en.wikipedia.org/wiki/Orlistat#Side_effects https://en.wikipedia.org/wiki/Orlistat#Side_effects

spondylosaurus 3y ago
> The manual for Alli makes it clear that orlistat treatment involves aversion therapy, encouraging the user to associate eating fat with unpleasant treatment effects. Christ. This is like Crohn's disease in pill form. One too many teaspoons of olive oil and you're in for an unpleasant evening...
- ortusdux 3y ago
  I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.
  - op00to 3y ago
    [flagged]
    - aidenn0 3y ago
      I want to frame this comment as an example of (the generalized form of) Poe's law.
      - op00to 3y ago
        It’s better to not know.
  - znpy 3y ago
    Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up. Does the fda allow that?
    - stavros 3y ago
      Yes, why would the FDA restrict what color pants you wear?
    - Retric 3y ago
      There’s huge tradeoffs people rarely talk about in Medicine. Significant risk of soiling yourself vs a statistically significant reduction in risk of early death isn’t a big deal for the FDA. In many cases the hell that is chemo is considered acceptable for even moderate increases in expected lifespan. That’s why people started talking healthy life expectancy vs just life expectancy.
      - AtlasBarfed 3y ago
        Well duh, if you discuss the side effects with patients, they won't take the drug and the drug people won't send you hookers.
        lazyasciiart 3y ago
        Bizarrely enough, the pressure doesn't always go in that direction.
- reaperman 3y ago
  I don't have a colon (but I do still have a functioning anus). The effects from orlistat are very similar to what I experience 24/7. If you're under 30 or so, eventually your sphincter gets much, much stronger and the excess oil stops affecting you nearly as much. You can hold it in indefinitely until your normal "need to go" timing. This takes about a year or so to train, and you'll have quite a few accidents in the meantime. I still can't eat too much salmon in one sitting though :-( I don't get diarrhea but I do get stuck on the toilet for ages after.
vrc 3y ago
Never trust a fart on orlistat. The horror stories I’ve read of people soiling themselves after eating seemingly normal meals is nuts. On par with Olestra/Haribo sugar-free stories. Also it makes absorbing fat soluble vitamins a huge issue.
- rhino369 3y ago
  The so called Alli-oops.
User23 3y ago
My favorite fat loss drug along these lines is dinitrophenol. It is the true miracle fat burning drug. It interferes with cellular metabolism in such a way that the body just nonstop oxidizes fat. Fat mass loss in the order of a pound a day or more is entirely possible and some bodybuilders use it to get to a ludicrously low bodyfat percentage. Unfortunately oxidizing that much fat generates a lot of heat, so much that an overdose can be lethal because your body literally roasts itself to death and titration is extremely difficult. Oh and blindness is a common side effect. And for added fun it’s an high explosive. Needless to say it’s not FDA approved.
- TylerE 3y ago
  > And for added fun it’s an high explosive Better not tell that to all the cardiac patients on nitroglycerin.
- desmosxxx 3y ago
  Also when you eat on it you are punished by heating up even more.
- xenospn 3y ago
  Permanent blindness?! Ffs
- reaperman 3y ago
  Honestly GLP-1 agonists will save lives just by being the go-to replacement for people who previously would have used DNP. GLP-1 agonists are effective enough that everyone in those circles basically stopped using DNP suddenly a couple years ago.
- justinclift 3y ago
  Is this the one? :) https://en.wikipedia.org/wiki/2,4-Dinitrophenol#Toxicity https://en.wikipedia.org/wiki/2,4-Dinitrophenol#Toxicity
etchasketch 3y ago
You want to know what's even crazier, you can literally but it over the counter. I was at kroger the other day and I saw it next to the vitamins and I did a double take.

spondylosaurus 3y ago

> The manual for Alli makes it clear that orlistat treatment involves aversion therapy, encouraging the user to associate eating fat with unpleasant treatment effects. Christ. This is like Crohn's disease in pill form. One too many teaspoons of olive oil and you're in for an unpleasant evening...

ortusdux 3y ago
I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.
- op00to 3y ago
  [flagged]
  - aidenn0 3y ago
    I want to frame this comment as an example of (the generalized form of) Poe's law.
    - op00to 3y ago
      It’s better to not know.
- znpy 3y ago
  Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up. Does the fda allow that?
  - stavros 3y ago
    Yes, why would the FDA restrict what color pants you wear?
  - Retric 3y ago
    There’s huge tradeoffs people rarely talk about in Medicine. Significant risk of soiling yourself vs a statistically significant reduction in risk of early death isn’t a big deal for the FDA. In many cases the hell that is chemo is considered acceptable for even moderate increases in expected lifespan. That’s why people started talking healthy life expectancy vs just life expectancy.
    - AtlasBarfed 3y ago
      Well duh, if you discuss the side effects with patients, they won't take the drug and the drug people won't send you hookers.
      - lazyasciiart 3y ago
        Bizarrely enough, the pressure doesn't always go in that direction.
reaperman 3y ago
I don't have a colon (but I do still have a functioning anus). The effects from orlistat are very similar to what I experience 24/7. If you're under 30 or so, eventually your sphincter gets much, much stronger and the excess oil stops affecting you nearly as much. You can hold it in indefinitely until your normal "need to go" timing. This takes about a year or so to train, and you'll have quite a few accidents in the meantime. I still can't eat too much salmon in one sitting though :-( I don't get diarrhea but I do get stuck on the toilet for ages after.

vrc 3y ago

Never trust a fart on orlistat. The horror stories I’ve read of people soiling themselves after eating seemingly normal meals is nuts. On par with Olestra/Haribo sugar-free stories. Also it makes absorbing fat soluble vitamins a huge issue.

rhino369 3y ago
The so called Alli-oops.

User23 3y ago

My favorite fat loss drug along these lines is dinitrophenol. It is the true miracle fat burning drug. It interferes with cellular metabolism in such a way that the body just nonstop oxidizes fat. Fat mass loss in the order of a pound a day or more is entirely possible and some bodybuilders use it to get to a ludicrously low bodyfat percentage. Unfortunately oxidizing that much fat generates a lot of heat, so much that an overdose can be lethal because your body literally roasts itself to death and titration is extremely difficult. Oh and blindness is a common side effect. And for added fun it’s an high explosive. Needless to say it’s not FDA approved.

TylerE 3y ago
> And for added fun it’s an high explosive Better not tell that to all the cardiac patients on nitroglycerin.
desmosxxx 3y ago
Also when you eat on it you are punished by heating up even more.
xenospn 3y ago
Permanent blindness?! Ffs
reaperman 3y ago
Honestly GLP-1 agonists will save lives just by being the go-to replacement for people who previously would have used DNP. GLP-1 agonists are effective enough that everyone in those circles basically stopped using DNP suddenly a couple years ago.
justinclift 3y ago
Is this the one? :) https://en.wikipedia.org/wiki/2,4-Dinitrophenol#Toxicity https://en.wikipedia.org/wiki/2,4-Dinitrophenol#Toxicity

etchasketch 3y ago

You want to know what's even crazier, you can literally but it over the counter. I was at kroger the other day and I saw it next to the vitamins and I did a double take.