Here is some data on the toxicity of carfentanil: > Carfentanil is one of the most potent opioids known. In rats and mice, the LD 50 of carfentanil is 3.39 and

Here is some data on the toxicity of carfentanil: > Carfentanil is one of the most potent opioids known. In rats and mice, the LD 50 of carfentanil is 3.39 and 18.75 mg/kg, respectively, after intravenous (IV) administration [1,2]. After intraperitoneal injection, lethality is observed at 326.4 μg/kg in rats and 83.1 μg/kg in ferrets [3, 4]. Signs of carfentanil intoxication including catalepsy, loss of righting reflex, and apnea/respiratory depression are observed at 18.2 and 8.92 μg/kg in rats and ferrets, respectively [3, 4]. The lowest reported lethal inhalation concentration in rats is 300 mg/m 3 [5], while exposure to concentrations as low as 0.4 mg/m 3 for 1 minute induces loss of consciousness in mice [6]. Because carfentanil has no approved human uses, the potency in humans has not been determined. It is estimate to be 100 times more potent than fentanyl and 10,000 times more potent than morphine, with an estimated lethal dose in humans of 20 μg (0.286 μg/kg) [7]. Data are available from one study in which healthy, non-drug using volunteers were given an IV bolus of 0.019 μg/kg carfentanil; dizziness, nausea, vomiting, and itching were observed [8] https://phc.amedd.army.mil/PHC%20Resource%20Library/InVitroDermalAbsorptionofCarfentanil.pdf https://phc.amedd.army.mil/PHC%20Resource%20Library/InVitroD...