5 ms·
There are effective alternatives which are a fraction of the cost: ketamine (sublingual ~100mg every few days), psilocybin (free? cheap 2-3g ~4 weeks), rapamyci
by radicaldreamer 3y ago
There are effective alternatives which are a fraction of the cost: ketamine (sublingual ~100mg every few days), psilocybin (free? cheap 2-3g ~4 weeks), rapamycin + ketamine also seems promising (https://www.nature.com/articles/s41386-020-0644-9 https://www.nature.com/articles/s41386-020-0644-9).
- wizzwizz4 3y agoI would recommend against trying to self-prescribe addictive substances.
- rozularen 3y agoI don't think any of those are addictive actually
- marcellus23 3y agojust because they're not chemically addictive doesn't mean they're not addictive. Weed isn't chemically addictive but plenty of people struggle with it nonetheless.
- blastro 3y agosame with food?
- marcellus23 3y agoWell, yes. That's what "food addiction" is.
- kyleyeats 3y agoWeed is chemically addictive. Your endocannabinoid system is downregulated for weeks after heavy use. You get withdrawal symptoms which are alleviated by use. I've never seen the phrase "chemically addictive" used by someone who knew what they were talking about. It's only used by people who don't understand that neurotransmitters are chemicals too. Stop spreading this BS distinction.
- mtlmtlmtlmtl 3y agoYeah, a lot of the withdrawal symptoms are so mild or transient people don't think of them as withdrawal or even make the connection. And people seem to think that anything less severe than shivering and unbearable pain, delirium, doesn't qualify as withdrawal. The most memorable withdrawal symptom from weed for me was the sweating. Cannabinoids tend to affect the hypothalamus which is sort of like the brain's control module for the endocrine system. And one of the things it controls is temperature regulation. So if you quit cold turkey that all gets outta wack and the sweating happens. Takes at least a couple of weeks to get somewhat back to normal.
- hirvi74 3y agoCorrect me if I am mistaken, but aren't withdrawal symptoms more indicative of a dependency than an addiction? Cessation of SSRIs can have all kinds of symptoms depending on the time length of usage, but I have never heard someone claim to be addicted to SSRIs.
- deleted 3y ago[deleted]
- marcellus23 3y agoI agree with you. I should have put "chemically addictive" in scare-quotes to make it clear that I think the distinction is silly.
- kyleyeats 3y agoMy bad and no offense. I'm a reader darkly. Italics/asterisks are also good.
- radicaldreamer 3y agoPsilocybin’s addictive potential is limited to at least 1 week intervals since it would have no effect if taken more often. Most people “addicted” wait much longer than that — sometimes months to make sure they have a strong trip and offset receptor down-regulation to the point where it can hardly be called an addiction.
- wizzwizz4 3y agoKetamine is definitely addictive for a lot of people. Rapamycin isn't one I've heard of before, but it looks like a does-lots-of-things drug: Wikipedia says it's an immunosuppressant. I'd recommend against DIYing that for a different reason.
- radicaldreamer 3y agoKetamine at the doses prescribed for treating depression has low addictive potential. The doses used recreationally are multiples of what is regimen for anti-depressive effects.
- q845712 3y agoI was hoping you were going to link to a DIY tms, so i will: https://www.instructables.com/Transcranial-Magnetic-Stimulation-TMS-Device/ https://www.instructables.com/Transcranial-Magnetic-Stimulat... Note the disclaimers, especially "TOUCHING THE DEVICE WRONG DURING ASSEMBLY CAN INSTANTLY KILL YOU. THIS DEVICE COULD KILL YOU OR MAIM YOU OR BREAK YOUR MIND." However the other things you're posting are alternative chemical treatments. People with resistant depression have already tried the approved chemical remedies. While I broadly agree that there's evidence in favor of both psilocybin and ketamine being potent chemical anti-depressants, I also think there's a number of valid reasons for someone to reach a point where they don't want to try any other chemical remedies, and ECT / TMS become more compelling options.
- radicaldreamer 3y agoWow, I didn’t even consider that there’s a DIY version of the equipment.
- lethologica 3y agoWith a warning like that, it might be worth trying if you’re suicidal! Nothing to lose! This is a joke of course…