3 ms·
Really frustrating there is no open access to this paper. I carry four (as far as I know) rare and low frequency homozygous minor allele SNPs in RELN: rs39335
by FollowingTheDao 3y ago
Really frustrating there is no open access to this paper.
I carry four (as far as I know) rare and low frequency homozygous minor allele SNPs in RELN:
rs39335(G;G)
rs3914132(C;C)
rs7696175(C;C)
rs4298437(T;T)
And guess what? I have Bipolar Disorder Schizoaffective type and my therapists keep telling me I have Aspergers.
This gene seems to bind to zinc, and a deficiency of zinc is also found in Alzheimer's.
https://www.jneurosci.org/content/41/13/3025#:~:text=Inflammatory%20lifestyle%20factors%20increase%20the,evidence%20for%20this%20is%20limited https://www.jneurosci.org/content/41/13/3025#:~:text=Inflamm....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010690/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010690/
https://alzres.biomedcentral.com/articles/10.1186/s13195-021-00931-3 https://alzres.biomedcentral.com/articles/10.1186/s13195-021...
Zinc has helped me in many ways.
Since the mutation is a GAIN OF FUNCTION mutation, more zinc means less risk of Alzheimer's.
- panax 3y agoIt is open access though, and linked at the bottom of the article: https://www.nature.com/articles/s41591-023-02318-3 https://www.nature.com/articles/s41591-023-02318-3
- FollowingTheDao 3y agoThanks, still cannot fine the SNP for the RELN-H3447R mutant though...
- elsherbini 3y agoI believe it is rs201731543 Found it by going to the list of all alleles of that gene (https://ensembl.org/Homo_sapiens/Transcript/Variation_Transcript/Table?db=core;g=ENSG00000189056;r=7:103471789-103989658;t=ENST00000428762 https://ensembl.org/Homo_sapiens/Transcript/Variation_Transc...) and looking for one that changes the 3444th amino acid from an H to an R
- FollowingTheDao 3y agoThank you! Too bad 23andMe does not pull that SNP.
- jamiek88 3y agoCan you recommend a zinc supplement? Preferably NSF or Mayo tested?
- FollowingTheDao 3y agoZinc Sulphate is the hospital approved form. But zinc picolinate will work well too. I take zinc sulfate. 220 mg with 50mg of elemental zinc.
- astrange 3y agoThat is rather high and may cause side effects for most people. (Those are: tingling in fingers, vivid dreams, and especially bad nausea and stomach pain. Also higher testosterone and dramatically higher sex drive, though maybe you like that.)
- FollowingTheDao 3y agoI agree, and I don’t recommend anyone take zinc before getting their zinc levels tested. Or if they know they have genetic issues with zinc and zinc deficiency. But the side effects from the zinc could be from a deficiency as well. If you are low in serotonin and dopamine and take zinc, it will increase these, and since you were low for so long, the reaction to higher levels will be more pronounced. The increase in serotonin is usually what causes stomach upset, and diarrhea. So it’s probably better for people who haven’t taken zinc who are deficient to start slowly.
- LoganDark 3y ago...Zinc can increase dopamine? I wonder what it would do to someone with ADHD.
- FollowingTheDao 3y agoProbably help some of them: https://www.nature.com/articles/s41598-021-94124-5 https://www.nature.com/articles/s41598-021-94124-5 B6 increases dopamine so that might play a role as well.
- ycombinete 3y agoHow did you find these alleles?
- FollowingTheDao 3y agoI uploaded my 23andMe raw data to promethease.con and searched for the gene.