8 ms·
The problem with this study is even more profound. They only looked at two military bases. One with high TCE, and one with low TCE. ...but there could be tho
by q1w2 3y ago
The problem with this study is even more profound.
They only looked at two military bases. One with high TCE, and one with low TCE.
...but there could be thousands of causal differences between two locations. They should have looked at dozens of military bases across the country/world.
- jameshart 3y agoWhy? This wasn’t a fishing expedition where they took two cohorts of marines and looked down a list of 20 diseases to find one with p<0.05 distribution between the two cohorts. > Occupational exposure to the industrial solvent trichloroethylene (TCE) was previously associated with a 6-fold increased risk of Parkinson disease (PD) in a small study of twin pairs discordant for PD.1 Animal studies provide biological plausibility for this association by recapitulating key pathologic characteristics of PD Given this - a previous finding, a plausible mechanism - they went and found two good existing cohorts who had different exposure to the compound of interest and for whom they could access medical records. That is good study design. Which is probably why it got published.