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Is there any evidence it actually reduces those risks, or is it speculation?

by enkid 3y ago

voisin 3y ago
Mitochondrial disfunction is the basis for a huge number of cancers. See “Tripping over the Truth: The Metabolic Theory of Cancer”[0] for a good history of it. [0] https://www.goodreads.com/book/show/23496164 https://www.goodreads.com/book/show/23496164
- MrBuddyCasino 3y ago
  Ray Peat liked this comment.
Alex3917 3y ago
Go on Google Scholar and read through the research on Metformin. Metformin has a complex mechanism of action, acting is as a Mitochondrial Complex 1 inhibitor in some cases but not others. But the consensus seems to be that it reduces cancer risk by about 30%, relating to its capacity as a Mitochondrial Complex 1 inhibitor. Also, if watch Jerry McLaughlin's YouTube talks about pawpaws and cancer, he summarizes the research that mainly focuses on the mechanisms of action of annonaceous acetogenins in fighting cancer -- these are also Mitochondrial Complex 1 inhbitors, similar to Metformin but much stronger. Basically these chemicals cause a buildup of radical oxides in your mitochondria, which reduce their efficiency. If your mitochondria have too many radical oxides, or have them for two long, then your mitochondria will die. And if enough mitochondria in any given cell die, their host cells will also obviously die. This is what causes progressive supranuclear palsy, which is what this article is probably (incorrectly) referring to as Parkinson's. But because the metabolic needs of cancer cells are higher than the metabolic needs of non-cancer cells, there may be a certain dose of these chemicals that is high enough to inhibit cancer but low enough that it doesn't cause palsy. Further, the way that cancer cells often develop resistance to chemotherapy drugs is by using ATP to pump out the drugs once they have entered the cells. These mitochondrial complex 1 inhibitors can prevent these protein pumps from working by making the mitochondria less efficient, and therefor effectively prevent cancer cells from developing certain types of resistance to chemotherapy drugs. Basically if you go through Google Scholar and read the research on pawpaws, rotenone, graviola, and Metformin, it's all more or less the same stuff. John Clifton's book Your Fourth Choice is also a fun book you can get on Amazon and read in an hour or two. It does a good job summarizing the academic research on annonaceous acetogenins. (I bought it because I collect books on North American Pawpaws, not because I was in the market for an experimental cancer treatment.)

Is there any evidence it actually reduces those risks, or is it speculation?

by enkid 3y ago

Is there any evidence it actually reduces those risks, or is it speculation?

Mitochondrial disfunction is the basis for a huge number of cancers. See “Tripping over the Truth: The Metabolic Theory of Cancer”[0] for a good history of it. [0] https://www.goodreads.com/book/show/23496164 https://www.goodreads.com/book/show/23496164

MrBuddyCasino 3y ago
Ray Peat liked this comment.

Alex3917 3y ago

Go on Google Scholar and read through the research on Metformin. Metformin has a complex mechanism of action, acting is as a Mitochondrial Complex 1 inhibitor in some cases but not others. But the consensus seems to be that it reduces cancer risk by about 30%, relating to its capacity as a Mitochondrial Complex 1 inhibitor. Also, if watch Jerry McLaughlin's YouTube talks about pawpaws and cancer, he summarizes the research that mainly focuses on the mechanisms of action of annonaceous acetogenins in fighting cancer -- these are also Mitochondrial Complex 1 inhbitors, similar to Metformin but much stronger. Basically these chemicals cause a buildup of radical oxides in your mitochondria, which reduce their efficiency. If your mitochondria have too many radical oxides, or have them for two long, then your mitochondria will die. And if enough mitochondria in any given cell die, their host cells will also obviously die. This is what causes progressive supranuclear palsy, which is what this article is probably (incorrectly) referring to as Parkinson's. But because the metabolic needs of cancer cells are higher than the metabolic needs of non-cancer cells, there may be a certain dose of these chemicals that is high enough to inhibit cancer but low enough that it doesn't cause palsy. Further, the way that cancer cells often develop resistance to chemotherapy drugs is by using ATP to pump out the drugs once they have entered the cells. These mitochondrial complex 1 inhibitors can prevent these protein pumps from working by making the mitochondria less efficient, and therefor effectively prevent cancer cells from developing certain types of resistance to chemotherapy drugs. Basically if you go through Google Scholar and read the research on pawpaws, rotenone, graviola, and Metformin, it's all more or less the same stuff. John Clifton's book Your Fourth Choice is also a fun book you can get on Amazon and read in an hour or two. It does a good job summarizing the academic research on annonaceous acetogenins. (I bought it because I collect books on North American Pawpaws, not because I was in the market for an experimental cancer treatment.)