Yes that's what hydrophobic/hydrophilic zones are for! Your quote is literally from the "Hydrophobic effect" section of that wikipedia article under "Driving fo

Yes that's what hydrophobic/hydrophilic zones are for! Your quote is literally from the "Hydrophobic effect" section of that wikipedia article under "Driving forces of protein folding" that explains exactly what I was talking about. The first proteins with those features evolved tens or hundreds of millions of years after the polypeptides that are the subject of this research. > Conformations differ based on environmental factors as well; similar proteins fold differently based on where they are found. https://en.wikipedia.org/wiki/Protein_folding#Primary_structure https://en.wikipedia.org/wiki/Protein_folding#Primary_struct...