Is it known what the mechanism is for metformin's effect on longevity? If it's due to its ability to reduce blood glucose levels, then berberine may be anothe

Is it known what the mechanism is for metformin's effect on longevity? If it's due to its ability to reduce blood glucose levels, then berberine may be another way to get a similar effect. Berberine stimulates glucose transport through a mechanism distinct from insulin https://www.sciencedirect.com/science/article/pii/S0026049506003908?via%3Dihub https://www.sciencedirect.com/science/article/pii/S002604950... Efficacy of Berberine in Patients with Type 2 Diabetes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/ It also lowers cholesterol Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins https://www.nature.com/articles/nm1135 https://www.nature.com/articles/nm1135 But pure berberine is not absorbed very well in the intestines, so you need to buy a good formation for it. Enhancement of sodium caprate on intestine absorption and antidiabetic action of berberine https://www.ncbi.nlm.nih.gov/pubmed/20237966/ https://www.ncbi.nlm.nih.gov/pubmed/20237966/ Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability https://pubmed.ncbi.nlm.nih.gov/24607213/ https://pubmed.ncbi.nlm.nih.gov/24607213/ The best thing might be to cook with barberries: https://thecaspianchef.com/2020/01/18/zereshk-polo-saffron-barberry-rice-pilaf/ https://thecaspianchef.com/2020/01/18/zereshk-polo-saffron-b...