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There are enough cases of identical twins where one twin gets it and the other doesn't that we are certain it can't just be genetic. We are also certain that g

There are enough cases of identical twins where one twin gets it and the other doesn't that we are certain it can't just be genetic. We are also certain that genes matter. We even know roughly which genes and that many of the variants that increase the risk are de novo mutations. We don't know much more than that, though.

deleted 3y ago
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NoMoreNicksLeft 3y ago
It's difficult to believe that there are many sets of identical twins out there where one was abused and the other treated well or whatever. Were these identicals raised apart, or together? Are there enough of each to see a difference in rates between those raised together and apart? Whatever the triggers are, I can't help but think that they're subtle and unmemorable.
balfirevic 3y ago
> There are enough cases of identical twins where one twin gets it and the other doesn't that we are certain it can't just be genetic. Strictly logically speaking, this is consistent with it being genetic + random chance (where the odds are determined only by your genes) - meaning no identifiable environmental factors. Not saying it is (nor would I know).
jakeinspace 3y ago
My grandmother’s twin sister developed schizophrenia, while my grandmother did not (though she did eventually suffer from Alzheimer’s). I have a moderately elevated genetic risk, and it’s something I do keep in mind. I believe her sister developed schizophrenia shortly after the 2 were separated from each other when my grandmother left for college, which is interesting timing.
pazimzadeh 3y ago
So, epigenenic