Given closed-source nature of anti-cheat software it's probably impossible to tell for sure. ACs do scan the system, some games IIRC refuse to run in a VM. I

Given closed-source nature of anti-cheat software it's probably impossible to tell for sure. ACs do scan the system, some games IIRC refuse to run in a VM. I also recall reading about some AC checking if the user inputs seem to be too perfectly timed to prevent botting.