3 ms·
Do these two new drugs (lecanemab and donanemab) work the same way aducanemab does? Does that mean that the aducanemab results weren't a fluke and that the amyl
by alephxyz 3y ago
Do these two new drugs (lecanemab and donanemab) work the same way aducanemab does? Does that mean that the aducanemab results weren't a fluke and that the amyloid plaque hypothesis may in fact be true?
- zosima 3y agoYes, Aducanumab may very well have had mild efficacy in the high dose group. But clearly the two newer drugs appear superior. Especially, when considering the side-effect profile. It will be exciting to see how efficacious these amyloid-beta antibodies can become and there is also clearly a small mystery (or at least a lack of consensus) in why the newer drugs show efficacy and the previous ones all failed.
- DANmode 3y agoIs plaque potentially 'just" a severely complicating factor more than a cause?
- loo 3y agoMaybe it's like "low serotonin levels" is to depression. A mechanism through which some effects are expressed, but not the root cause, and only one aspect of the condition.