> many people don't develop resistance, or at least not for a loooong time Yes, but I have also seen people who used biologics for 10 years without issue, and

> many people don't develop resistance, or at least not for a loooong time Yes, but I have also seen people who used biologics for 10 years without issue, and out of the blue they started to have severe side effects that made them move drop off (or move to another one). You just never know.