4 ms·
Actually, it's complicated, and there really isn't consensus one way or another. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949415/ https://www.ncbi.nlm.nih
by vitus 3y ago
Actually, it's complicated, and there really isn't consensus one way or another.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949415/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949415/
"Seventeen meta-analyses of these studies have been performed and have similarly shown conflicting results with some demonstrating a survival advantage (4-6) while other have not (7-10). Consequently, true equipoise exists with regards to the clinical benefit of corticosteroids in patients with severe sepsis and septic shock.
...
In summary, the use of corticosteroids in patients with severe sepsis and septic shock is not associated with improved patient centered outcomes, however this treatment is safe and without an increased risk of complications. Corticosteroids appear to have synergistic biological effects when combined with intravenous vitamin C and thiamine and may be associated with improved patient centered outcomes (21)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604467/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604467/
"In this review article, we reviewed a total of eight different articles being done in last 10 years, relevant to the clinical outcome and effects of corticosteroids. Among those, two demonstrated improved clinical outcomes, two showed both improved clinical outcomes and decreased mortality, three showed increased adverse effects, and the remaining one showed unequivocal results."
- giantg2 3y agoInteresting