3 ms·

https://en.wikipedia.org/wiki/Clostridioides_difficile_infection#Cause https://en.wikipedia.org/wiki/Clostridioides_difficile_infec... There is no mention on y

https://en.wikipedia.org/wiki/Clostridioides_difficile_infection#Cause https://en.wikipedia.org/wiki/Clostridioides_difficile_infec... There is no mention on your page, or the wiki, that antibiotics are the cause the resistant bacteria. I can logically see why we would believe this, but you'd expect given the use of antibiotics on the farm and in non US pharmacies; we'd have such a superbug scientifically proven by now.

anonymouskimmer 4y ago
Scientifically it's nearly impossible to prove things. However, scientific evidence supporting the antibiotic-driven increase in antibiotic resistant "superbugs" has been found. https://www.theguardian.com/environment/2019/sep/19/superbug-hotspots-emerging-in-farms-across-globe-study https://www.theguardian.com/environment/2019/sep/19/superbug... Antibiotics, and antibiotic resistance genes, have existed for an uncountable number of megayears. Antibiotic use by humans is probably not creating many new antibiotic resistance genes, if any at all. But is is driving the increase in bacteria that contain these genes, as well as encouraging the horizontal transmission of antibiotic resistance genes and the accumulation of multiple such genes in so-called "superbugs". https://www.nature.com/articles/s41467-021-22757-1 https://www.nature.com/articles/s41467-021-22757-1 https://pubmed.ncbi.nlm.nih.gov/30248271/ https://pubmed.ncbi.nlm.nih.gov/30248271/ https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01040-y https://genomemedicine.biomedcentral.com/articles/10.1186/s1...
yarg 4y ago
It's a fairly clear case of natural selection.
Fomite 4y ago
One of the biggest risk factors for a C. difficile infection is being treated with fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, and ofloxacin), which are often used in outpatient settings.

anonymouskimmer 4y ago

Scientifically it's nearly impossible to prove things. However, scientific evidence supporting the antibiotic-driven increase in antibiotic resistant "superbugs" has been found. https://www.theguardian.com/environment/2019/sep/19/superbug-hotspots-emerging-in-farms-across-globe-study https://www.theguardian.com/environment/2019/sep/19/superbug... Antibiotics, and antibiotic resistance genes, have existed for an uncountable number of megayears. Antibiotic use by humans is probably not creating many new antibiotic resistance genes, if any at all. But is is driving the increase in bacteria that contain these genes, as well as encouraging the horizontal transmission of antibiotic resistance genes and the accumulation of multiple such genes in so-called "superbugs". https://www.nature.com/articles/s41467-021-22757-1 https://www.nature.com/articles/s41467-021-22757-1 https://pubmed.ncbi.nlm.nih.gov/30248271/ https://pubmed.ncbi.nlm.nih.gov/30248271/ https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01040-y https://genomemedicine.biomedcentral.com/articles/10.1186/s1...

yarg 4y ago

It's a fairly clear case of natural selection.

Fomite 4y ago

One of the biggest risk factors for a C. difficile infection is being treated with fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, and ofloxacin), which are often used in outpatient settings.