Air defense has had automatic targeting since the 1980s(?) due to the required reaction times. As for autonomous target/kill programs, that'd be the USAF's Col

Air defense has had automatic targeting since the 1980s(?) due to the required reaction times. As for autonomous target/kill programs, that'd be the USAF's Collaborative Combat Aircraft (CCA) program (under NGAD). It sounds like they're keeping human-in-the-loop for now by targeting a 1:many manned_stealth:drone ratio, but that will be subject to erosion as autonomous capabilities improve. And the very nature of the mission requires autonomy -- drones penetrating deep into sophisticated air defense systems using stealth and emissions control (so only line-of-sight communication links). Nobody is going to be remotely piloting these things.