3 ms·

This is everything and nothing all at once. Synucleinopathies are found in many neurological diseases. They even find it in Long COVID. https://www.ncbi.nlm.n

This is everything and nothing all at once. Synucleinopathies are found in many neurological diseases. They even find it in Long COVID. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108014/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108014/ This is a marker for many diseases. They still have not found the trigger for Synucleinopathies, which I believe is a nutrient deficiency causing oxidative stress and zinc is at the top of my list. https://academic.oup.com/hmg/article/23/11/2791/621896 https://academic.oup.com/hmg/article/23/11/2791/621896 https://academic.oup.com/brain/article/142/8/2380/5523051 https://academic.oup.com/brain/article/142/8/2380/5523051 By the way, this is the same reason peop[le loose their sense of smell with COVID. And I believe COVID is going to cause a rise in Parkinson's cases.

giantg2 4y ago
If the loss of smell is so brief, why would it cause this later?
- FollowingTheDao 4y ago
  It might not. If the build up of alpha-synuclein is rapid during COVID that might only cause a temporary issue if the person can still break it down. These people might not go on to get Parkinson's. Matrix metalloproteinases break down alpha-synuclein. https://pubmed.ncbi.nlm.nih.gov/21330369/ https://pubmed.ncbi.nlm.nih.gov/21330369/ And it's cofactor, the metal that increases MMP3 activity is zinc (and calcium). https://www.uniprot.org/uniprotkb/P08254/entry https://www.uniprot.org/uniprotkb/P08254/entry This is why I keep screaming that zinc is probably a central deficiency to both of these disorders in some people.