3 ms·

https://www.michaeljfox.org/news/thiamine-vitamin-b1-and-parkinsons https://www.michaeljfox.org/news/thiamine-vitamin-b1-and-par... The Michael J Fox foundatio

https://www.michaeljfox.org/news/thiamine-vitamin-b1-and-parkinsons https://www.michaeljfox.org/news/thiamine-vitamin-b1-and-par... The Michael J Fox foundation is more muted and says evidence is still missing. There have only been 2 trials and both were missing a placebo control group.

huhtenberg 4y ago
It's for the US and Canada only.
oefnak 4y ago
Imagine having Parkinsons and being in the placebo control group.
- chris-orgmenta 3y ago
  If a treatment in a placebo controlled study shows a vast improvement over placebo, the studies are sometimes finished early and are considered 'unethical to continue'. e.g. HAART for HIV/AIDS.
- wyldfire 4y ago
  Today we should assume that it's harmless to get the placebo. Only if a trial shows extraordinary consistent benefit without drawbacks would they stop it because the placebo group is harmed for lack of access to the treatment.
- DavidPiper 4y ago
  I used to share this sentiment for Parkinsons and other currently-intractable conditions. I still do sometimes, depending on the circumstances of the patient in question. But the thing that stopped me generalising this was seeing second-hand that trialing a new treatment can be extraordinarily dangerous (and/or fatal). Imagine being in the experiment group and the untested treatment being a catastrophic failure.
- NobleLie 4y ago
  Imagine symptoms improving being in the placebo group? What are the statistics on that?
- mypalmike 4y ago
  Being part of a rigorous process by which a cure may be found? Sign me up.
- Cthulhu_ 4y ago
  You're thinking that even a gamble on untested / unverified treatment might improve their lives; it might, but it might also do nothing, make it work, or worst case kill them. But I get it. My partner has an untreatable condition (like EDS, but without the genetic markers); they'd jump on any kind of hope, even experimental at this point.

huhtenberg 4y ago

It's for the US and Canada only.

oefnak 4y ago

Imagine having Parkinsons and being in the placebo control group.

chris-orgmenta 3y ago
If a treatment in a placebo controlled study shows a vast improvement over placebo, the studies are sometimes finished early and are considered 'unethical to continue'. e.g. HAART for HIV/AIDS.
wyldfire 4y ago
Today we should assume that it's harmless to get the placebo. Only if a trial shows extraordinary consistent benefit without drawbacks would they stop it because the placebo group is harmed for lack of access to the treatment.
DavidPiper 4y ago
I used to share this sentiment for Parkinsons and other currently-intractable conditions. I still do sometimes, depending on the circumstances of the patient in question. But the thing that stopped me generalising this was seeing second-hand that trialing a new treatment can be extraordinarily dangerous (and/or fatal). Imagine being in the experiment group and the untested treatment being a catastrophic failure.
NobleLie 4y ago
Imagine symptoms improving being in the placebo group? What are the statistics on that?
mypalmike 4y ago
Being part of a rigorous process by which a cure may be found? Sign me up.
Cthulhu_ 4y ago
You're thinking that even a gamble on untested / unverified treatment might improve their lives; it might, but it might also do nothing, make it work, or worst case kill them. But I get it. My partner has an untreatable condition (like EDS, but without the genetic markers); they'd jump on any kind of hope, even experimental at this point.