I think chronic over-usage is a more serious concern. Taking even handful of pills is not that likely to result in permanent damage (unlike paracetamol). Up to

I think chronic over-usage is a more serious concern. Taking even handful of pills is not that likely to result in permanent damage (unlike paracetamol). Up to 100 mg/kg shouldn't be that risky (so 20 400mg pills for somebody who weighs 80kg)