Are there arguments to that to tile it by columns first instead of rows? (but not one long column all the way down the left to the end and then one long column

Are there arguments to that to tile it by columns first instead of rows? (but not one long column all the way down the left to the end and then one long column on the right, just want to shuffle the order on each page). It reads kind of r/nosafetysmokingfirst to me. (And its `brew install texlive` on mac to get pdfxup for anyone else wondering)