I want to be as optimist as the author. But it's hard to not believe the existence of a "low-hanging fruit depletion" dynamic in science, at least the hard scie

I want to be as optimist as the author. But it's hard to not believe the existence of a "low-hanging fruit depletion" dynamic in science, at least the hard sciences, to some degree. At least the material and equipment costs tend to go higher.