I guess that depends on what you count as a breakthrough. From my perspective, HiC is a small detail, and even AlphaFold is just the latest improvement to an ex

I guess that depends on what you count as a breakthrough. From my perspective, HiC is a small detail, and even AlphaFold is just the latest improvement to an existing process. A true breakthrough would be something like ancient DNA, which gave the humanity a new tool for studying the past. Pretty much everything in genomics depends on shotgun sequencing, which in turn depends on CS. The algorithms used for assembling something useful out of the sequence reads are highly non-obvious. In fact, most developments in string algorithms since the 80s have been driven by the needs of DNA sequencing. (Information retrieval used to be another contender, but word tokens turned out to be a better tool for that field.)