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I'm surprised as well. I thought the problem with cancer is that the immune system doesn't react/detect it and therefore might not provide a discernible signal.
by genomer 3y ago
I'm surprised as well. I thought the problem with cancer is that the immune system doesn't react/detect it and therefore might not provide a discernible signal.
- nextos 3y agoSure, that's the problem with cancer. But to get there first, your immune repertoire has become less diverse and developed some holes due to infections, dysbiosis, aging, etc.
- kuhewa 3y agoThere's usually going to be some signal though even if it was just localized downregulation of some proteins on immune cells induced by a cancer to escape detection. The trouble there is that may be swamped in a systemic serum sample. Looking at subsets are more useful to improve signal to noise ratio like looking at extracellular vesicles released by tumour and immune cells for messaging purposes