The big problem with the Space Shuttle was that the orbiter was located next to the fuel tank and between the solid boosters instead of on top of it. This made

The big problem with the Space Shuttle was that the orbiter was located next to the fuel tank and between the solid boosters instead of on top of it. This made it impossible to perform the normal "accelerate away from the big boom" manoeuvre which normal rocket escape systems use. On Starship the passengers will be situated above the explosives instead of next to them/between them. As to whether it is possible to add escape engines of sufficient power to pull away the nose cone, push it up into a parabolic trajectory of sufficient height to give parachutes the chance to deploy I don't know but at least it could be done in theory where the design of the Space Shuttle and its "close cousin" Buran made this impossible.