> It's been clear since the beginning that it's psychedelic-assisted therapy — not just psychedelics — that makes the treatment effective. Thank you for pointi

> It's been clear since the beginning that it's psychedelic-assisted therapy — not just psychedelics — that makes the treatment effective. Thank you for pointing this out. This is the key point that so many people miss by skimming the headlines. These medication-assisted therapy trials are about the therapy first and foremost. Some of the trials have several dozen therapy sessions in their protocols and only a single or couple medication-assisted sessions. People taking these drugs on their own at home are not doing anything resembling the therapy discussed in these trials. There are numerous stories of people taking psychedelics ad-hoc and ending up with worsened anxiety, derealization, persistent fears, delusional thoughts, and so on. The common wisdom in psychedelic circles was that set and setting is everything - Taking psychedelics while in a state of depression, anxiety, PTSD, or other conditions outside of the setting of closely monitored professional therapy is potentially quite negative.