5 ms·
Most interesting. There are even easier and more direct ways to improve resistance to glaucoma; namely high dose nictotinamide (aka niacinamide aka non-flushing
by robwwilliams 4y ago
Most interesting. There are even easier and more direct ways to improve resistance to glaucoma; namely high dose nictotinamide (aka niacinamide aka non-flushing vitamin B3, aka NAM).
The key paper was published in Science in 2017 by Pete Williams, Simon John and colleagues in mice.
https://pubmed.ncbi.nlm.nih.gov/28209901/ https://pubmed.ncbi.nlm.nih.gov/28209901/
Vit B3 at relatively high dose (1 to 4 gm/day) is now being tested in several human clinical trials for glaucoma and other forms of neurodegenerative and neurocognitive age-related diseases.
See ClinicalTrsil.giv
https://clinicaltrials.gov/ct2/results?cond=Glaucoma&term=nicotinamide&cntry=&state=&city=&dist= https://clinicaltrials.gov/ct2/results?cond=Glaucoma&term=ni...
Results are promising, but like most therapeutics the efficacy is likely to vary by genotype, disease subtype, age, diet etc.
I’ve been taking 3 g/day for 6 years and have noticed improvements in cognitive function (recall, speech speed). But I freely admit that this could be placebo effect or due to weight loss and more exercise, so take my n=1 uncontrolled trial with big grain of salt.
- nose 4y agoDo you take a B complex vitamin or exclusively B3?
- rpaddock 4y agoTaking any single B vitamin can deplete other B vitamins. It is best to take a B Complex as a baseline and add to that.
- robwwilliams 4y agoNot all B vitamins have a wide safety profile, so I consider this poor advice if your goal is to get to 3 g/day of B3. Do you have citation specific for B3?
- robwwilliams 4y agoJust niacinamide—non-flushing B3.
- pazimzadeh 4y agoDid you test your blood levels first or just start taking it? Does it affect your sleep at all? Does it matter if you take it in the morning/night? Do you only benefit from the high dose? Do you take 3 grams all at once, or with meals?
- robwwilliams 4y agoYour mileage may vary but here is a brief set of answers. I just started taking it given advice from experts in glaucoma. This vitamin has great safety profile even at 5 g/day oral. But source it carefully from reputable manufacturer. Yes, initially my sleep improved. I do not take before sleeping. Not critical: My typical pattern when at home is 1 gm x 3 time points spread through day, but it shouldn’t matter much. No adverse GI symptoms in 6 years.