4 ms·

Intranasal is only viable for people who are truly terrified of needles. Instead of a swollen arm you get the head cold experience. Never again; I hate getting

• ceejayoz 3y ago
  Intranasal vaccination is believed to be potentially more effective because the nasal mucosa are where it enters the body. From the link: > Some studies on respiratory viruses such as respiratory syncytial virus (RSV) and influenza virus provide substantial evidence that mucosal immunity is key to the effective control of respiratory viruses. > However, almost all COVID-19 vaccines approved for human usage, including inactivated virus, lipid nanoparticle-encapsulated mRNA, protein subunit of spike or RBD, and adenovirus vectored vaccines, are administered via intramuscular injection. These vaccines can induce a systemic immune response that protects against severe disease and mortality but not a mucosal immune response and are insufficient in preventing upper respiratory infection and transmission, especially with the emergence of highly transmissible Omicron subvariants.
  • smegsicle 3y ago
    tl;dr: different lymph nodes are activated by an injected vaccine than those which would be involved in first-line-defense against a real respiratory virus