4 ms·
Not an either-or situation at all. There is no one “more interesting track”. Always tradeoffs as I am sure you know. The key advances in this paper are four-fo
by robwwilliams 4y ago
Not an either-or situation at all. There is no one “more interesting track”. Always tradeoffs as I am sure you know.
The key advances in this paper are four-fold:
1: Much higher spatial resolution and contrast that is essential to define boundaries of brain regions
2. Much faster scan time using multiple angle acquisitions
3. Accurate segmentation of brain regions of interest even for highly diverse genomes of mice.
4. Accurate alignment and multimodal merging of MRI with 3D lightsheet microscopy from the same animal with fluorescent labelling of multiple CNS cell types.
fMRI in mice is limited in its resolution. To generate time series data we use large sets of isogenic (identical twin) mice. See figure 5 in the paper for a comparison of young and old mice that are identical twins—one a young adult and one quite old adult.