I would in fact argue that in large systems it is infeasible to have a load-balancer sit in between. Especially if you adopt a microservice-based architecture:

I would in fact argue that in large systems it is infeasible to have a load-balancer sit in between. Especially if you adopt a microservice-based architecture: it doesn't make sense for every microservice to have its own load balancer to proxy all traffic. Instead the load balancer simply assigns traffic to specific services without being in the middle. It is the client's responsibility to obey the load balancer's decision.