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It's actually neither nor. They just used the MRI to map a high-resolution image obtained via light sheet microscopy. I doubt you can do that with living anima
by Loquebantur 4y ago
It's actually neither nor.
They just used the MRI to map a high-resolution image obtained via light sheet microscopy. I doubt you can do that with living animals. Without slicing the brain that is.
The title here is highly misleading.
- tgbugs 4y agoThe number in the title is misleading but what you write here is also misleading. > The diffusion tensor images (DTI) @ 15 μm spatial resolution are 1,000 times the resolution of most preclinical rodent DTI/MRI. Superresolution track density images are 27,000 times that of typical preclinical DTI/MRI. The resolution of the raw MRI images is significantly higher, without that increased resolution it would be impossible to align the light sheet images. The light sheet images are not use to "improve" MRI resolution.
- kevviiinn 4y agoLight sheet microscopy is actually pretty neat. You can use it on a whole brain without slicing it but not on a living animal. The tissue needs to go through a special fixing procedure first
- robwwilliams 4y agoBut lightsheet only practical today for fairly small blocks of tissue. 1 centimeter cubes yes, but not much more.
- SquirrelOnFire 4y agoYeah, they kind of blow past light sheet microscopy, but I'm optimistic that this can still be quite useful. There are brain banks with already donated brains that we could use to learn about diseases, and I imagine many organ donors would be happy to have their brains sliced up for science.