7 ms·
Ask HN: Have you taken anti-aging supplements that reduced biological age?
I am curious to hear from anyone that has tried anti aging supplements and observed a measurable reduction in their biological age as a direct result of the supplements? I am equally interested in hearing from those that tried these, or similar supplements with no measurable reduction in biological age.
For those that observed a measurable reduction in biological age:
- What were the supplements & dosage?
- What was the measurable improvement?
Examples of such supplements:
Nicotinamide mononucleotide (NMN)
Resveratrol
Metformin
Statin
Alpha lipoic acid (ALA)
Coenzyme Q10 (coQ10)
Spermidine
Quercetin and fisetin
TMG (trimethylglycine or betaine)
- yamrzou 3y agoIf you're interested in longevity, I recommend the book “Outlive: The Science and Art of Longevity” by Peter Attia MD.
- jyu 4y agoJust a small warning. These supplements are less impactful than optimized sleep, exercise, diet, stress related to work or personal. It's difficult to change 1 variable while holding the others stable. I have also found measuring and interpreting different biomarkers nontrivial. Watching Michael Lustgarten's efforts is very relevant https://www.youtube.com/@conqueragingordietrying1797 https://www.youtube.com/@conqueragingordietrying1797
- dustfinger 4y agoThank you for introducing me to Michael Lustgarten's videos. I have never seen these before and am looking forward to watching them. > These supplements are less impactful than optimized sleep, exercise, diet, stress related to work or personal I suspect that is probably true. At the moment sleep / stress are a bit difficult for me to manage. I am improving the exercise and diet factors though.
- graypegg 4y agoGood sleep routines, regular exercise, and a balanced diet are so annoyingly effective at making your life better.
- adyashakti 4y ago[flagged]
- dustfinger 4y agoThank you, I will read up on that. Do you recommend any particular brand or source?
- gfd 4y agoFor skin, retinoids seem to work well. You can order one called Differin w/o prescription
- dustfinger 4y agoThank you, I did not know about retinoids. I have added this to my reading queue. It seems that prolonged usage can have undesirable side effects, but proper dosage is effective in treating a variety of skin conditions. In the case of reducing skin wrinkles, I wonder if that is purely cosmetic, or if it actually makes the skin healthier in some way?
- juvvel 4y agoYou can also apply retinoids topically. What it does is increasing collagen production.
- dustfinger 4y ago> What it does is increasing collagen production. That is really interesting. The potential side effects from toxicity listed on wikipedia [1] are ominous. I wish there was consumer technology to effectively monitor ones own blood work. [1]: https://en.wikipedia.org/wiki/Retinoid#Toxicity https://en.wikipedia.org/wiki/Retinoid#Toxicity
- croo 4y agoIf you are looking for a younger look, excercises exists that will stress your facial muscles. With a few months of training you can get a younger look. Of course that won't get you to live longer :)
- dustfinger 4y agoThank you! I am mainly interested in longevity, but maintaining both biological youth and a youthful appearance would be ideal.