4 ms·
Highly variable. In cancers they can be much larger. Mitochondrial circular DNA is about 16,600 basepairs. In comparison, in the paper below one example of a ca
by robwwilliams 4y ago
Highly variable. In cancers they can be much larger. Mitochondrial circular DNA is about 16,600 basepairs. In comparison, in the paper below one example of a cancer-driven ecDNA is 1,260,000 basepairs (EGFRvIII). ecDNA were originally detected using cytogenetic light microscopic methods, hence the original bias toward large size.
Wikipedia article: https://en.wikipedia.org/wiki/Extrachromosomal_DNA https://en.wikipedia.org/wiki/Extrachromosomal_DNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334176/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334176/