Cre-lox recombination is effectively payload-unlimited. Why create an artificial chromosome when inheritance is intended when you can just add to a current chro

Cre-lox recombination is effectively payload-unlimited. Why create an artificial chromosome when inheritance is intended when you can just add to a current chromosome? > perhaps by tethering against native chromosomes via zinc fingers, viral-encoded protein, or AT-hook motifs. It sounds complex. Partition loci would be sufficient for inheritance in both offspring cells.