5 ms·

Reading this gives me an understanding for how some of my friends feel when I talk about technology. “Make sure to set the dip switches on your SCSI drive and

Reading this gives me an understanding for how some of my friends feel when I talk about technology. “Make sure to set the dip switches on your SCSI drive and confirm your cable is USB 4+ PD.” Lol

matheusmoreira 4y ago
English Wikipedia is a surprisingly good resource. https://en.wikipedia.org/wiki/SiDNA https://en.wikipedia.org/wiki/SiDNA So these things interfere with genetic operations in the cell, including cancerous cells. There's some evidence linked showing they enhance cancer treatments. Radiotherapy works by inducing cell and DNA damage in cancer cells, and these siDNA hurt their ability to repair themselves. https://en.wikipedia.org/wiki/Extrachromosomal_circular_DNA https://en.wikipedia.org/wiki/Extrachromosomal_circular_DNA Circular strands of DNA that live outside the chromosome which are those X and Y things, a condensed form of DNA. Like a little DNA module floating about in the cell. What if you could develop new modules and deliver them to people's cells via viruses or something? Bacteria already have this capability - and more. https://en.wikipedia.org/wiki/Transformation_(genetics) https://en.wikipedia.org/wiki/Transformation_(genetics) Some of its friends died, releasing useful plasmids into the environment? They'll just absorb it. They're like the Mega Men of microbiology. Things die and they absorb their powers. https://en.wikipedia.org/wiki/Bacterial_conjugation https://en.wikipedia.org/wiki/Bacterial_conjugation Produce a literal pipe to transfer your antibiotic resistance super powers to your friend. Finally: https://en.wikipedia.org/wiki/Transduction_(genetics) https://en.wikipedia.org/wiki/Transduction_(genetics) Virus infects bacteria and adds its genetic material to it to make it produce copies. Those copies end up carrying some bacterial DNA in them though. This leads to some viruses turning into a DNA injection mechanism that transfer plasmids to other bacteria. Perhaps scientists will figure out how to use them to deliver DNA to our cells instead.
- chasil 4y ago
  Regarding plasmids, there is a similar mechanism of DNA exchange in human cells known as "gypsy transposons," that are viral fragments which were partially integrated into germline ancestry. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009535 https://journals.plos.org/plosgenetics/article?id=10.1371/jo...
  - matheusmoreira 4y ago
    So retroviruses literally integrated into our biological processes and became physiological? That's seriously awesome. https://en.wikipedia.org/wiki/Retrotransposon https://en.wikipedia.org/wiki/Retrotransposon > An endogenous retrovirus is a retrovirus without virus pathogenic effects that has been integrated into the host genome by inserting their inheritable genetic information into cells that can be passed onto the next generation like a retrotransposon. > When the retroviral DNA is integrated into the host genome they evolve into endogenous retroviruses that influence eukaryotic genomes.
    - chasil 4y ago
      I read recently that DNA transcription for protein expression is able to identify and skip an inserted element, but that the protein will be slightly different at the boundaries. It appears to have gone badly wrong for the "Tasmanian Devil." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802805/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802805/ https://www.science.org/content/article/origin-tasmanian-devil-tumors-identified https://www.science.org/content/article/origin-tasmanian-dev...
robocat 4y ago
Yeah, status seeking by using uncommon words or concepts, often noticeable in geek-culture. The same thing occurs in many cultures. “Well-educated” people in England might use more sophisticated[1] language and drop[2] references in Greek, Latin, or other languages of le très bien formées. “Elucidate” feels like a status signal in the OP’s comment. Personally one has been working on counter-signalling[3] by using simpler words and concepts, although one cannot say one is succeeding. [1] https://www.etymonline.com/word/sophisticated https://www.etymonline.com/word/sophisticated [2] fucked if I can find a good reference for my usage of “drop” here however hardly I tried [3] https://www.marketingsociety.com/the-library/counter-signalling-or-signalling-it’s-all-about-status https://www.marketingsociety.com/the-library/counter-signall... - I chose this link because it appears to be well written and uses “elucidate”[0], “dropped” and “aperçus”. [0] They go on to elucidate. Apparently if you… play strategy s* = ( s*, s*M, s*) where s* < s*M. Let μ describe beliefs that are Bayes consistent with playing s*. Then the expected gross payoff to sender q from signal s*M is Eμ[q´|s*M,q] = M … Yup, they rather lost me at that point.
- woleium 4y ago
  idk man, elucidate is pretty common if you spend a lot of time reading scientific papers (I'm assuming oop does).
  - deleted 4y ago
    [deleted]
  - staunton 4y ago
    Which only proves the point robocat was making
  - robocat 4y ago
    Exactly the point: well-educated people use words that appear in scientific papers. Showing you are well-educated is a common status signal amongst many well-educated people. Some people are lingual chameleons[1]: their language patterns completely change depending on their social surroundings. And many people are liguistic artistes[2] who choose their language to paint an image of themselves. However, failure is rife. [1] one Google result, different usage. [2] Sprachartisten
Dalewyn 4y ago
>confirm your cable is USB 4+ PD. I'm a tech nerd and wouldn't know WTF that means because USB is universally meaningless. Setting DIP switches is perfectly obvious, though. I miss the days messing with them and also jumpers.

matheusmoreira 4y ago

English Wikipedia is a surprisingly good resource. https://en.wikipedia.org/wiki/SiDNA https://en.wikipedia.org/wiki/SiDNA So these things interfere with genetic operations in the cell, including cancerous cells. There's some evidence linked showing they enhance cancer treatments. Radiotherapy works by inducing cell and DNA damage in cancer cells, and these siDNA hurt their ability to repair themselves. https://en.wikipedia.org/wiki/Extrachromosomal_circular_DNA https://en.wikipedia.org/wiki/Extrachromosomal_circular_DNA Circular strands of DNA that live outside the chromosome which are those X and Y things, a condensed form of DNA. Like a little DNA module floating about in the cell. What if you could develop new modules and deliver them to people's cells via viruses or something? Bacteria already have this capability - and more. https://en.wikipedia.org/wiki/Transformation_(genetics) https://en.wikipedia.org/wiki/Transformation_(genetics) Some of its friends died, releasing useful plasmids into the environment? They'll just absorb it. They're like the Mega Men of microbiology. Things die and they absorb their powers. https://en.wikipedia.org/wiki/Bacterial_conjugation https://en.wikipedia.org/wiki/Bacterial_conjugation Produce a literal pipe to transfer your antibiotic resistance super powers to your friend. Finally: https://en.wikipedia.org/wiki/Transduction_(genetics) https://en.wikipedia.org/wiki/Transduction_(genetics) Virus infects bacteria and adds its genetic material to it to make it produce copies. Those copies end up carrying some bacterial DNA in them though. This leads to some viruses turning into a DNA injection mechanism that transfer plasmids to other bacteria. Perhaps scientists will figure out how to use them to deliver DNA to our cells instead.

chasil 4y ago
Regarding plasmids, there is a similar mechanism of DNA exchange in human cells known as "gypsy transposons," that are viral fragments which were partially integrated into germline ancestry. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009535 https://journals.plos.org/plosgenetics/article?id=10.1371/jo...
- matheusmoreira 4y ago
  So retroviruses literally integrated into our biological processes and became physiological? That's seriously awesome. https://en.wikipedia.org/wiki/Retrotransposon https://en.wikipedia.org/wiki/Retrotransposon > An endogenous retrovirus is a retrovirus without virus pathogenic effects that has been integrated into the host genome by inserting their inheritable genetic information into cells that can be passed onto the next generation like a retrotransposon. > When the retroviral DNA is integrated into the host genome they evolve into endogenous retroviruses that influence eukaryotic genomes.
  - chasil 4y ago
    I read recently that DNA transcription for protein expression is able to identify and skip an inserted element, but that the protein will be slightly different at the boundaries. It appears to have gone badly wrong for the "Tasmanian Devil." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802805/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802805/ https://www.science.org/content/article/origin-tasmanian-devil-tumors-identified https://www.science.org/content/article/origin-tasmanian-dev...

robocat 4y ago

Yeah, status seeking by using uncommon words or concepts, often noticeable in geek-culture. The same thing occurs in many cultures. “Well-educated” people in England might use more sophisticated[1] language and drop[2] references in Greek, Latin, or other languages of le très bien formées. “Elucidate” feels like a status signal in the OP’s comment. Personally one has been working on counter-signalling[3] by using simpler words and concepts, although one cannot say one is succeeding. [1] https://www.etymonline.com/word/sophisticated https://www.etymonline.com/word/sophisticated [2] fucked if I can find a good reference for my usage of “drop” here however hardly I tried [3] https://www.marketingsociety.com/the-library/counter-signalling-or-signalling-it’s-all-about-status https://www.marketingsociety.com/the-library/counter-signall... - I chose this link because it appears to be well written and uses “elucidate”[0], “dropped” and “aperçus”. [0] They go on to elucidate. Apparently if you… play strategy s* = ( s*, s*M, s*) where s* < s*M. Let μ describe beliefs that are Bayes consistent with playing s*. Then the expected gross payoff to sender q from signal s*M is Eμ[q´|s*M,q] = M … Yup, they rather lost me at that point.

woleium 4y ago
idk man, elucidate is pretty common if you spend a lot of time reading scientific papers (I'm assuming oop does).
- deleted 4y ago
  [deleted]
- staunton 4y ago
  Which only proves the point robocat was making
- robocat 4y ago
  Exactly the point: well-educated people use words that appear in scientific papers. Showing you are well-educated is a common status signal amongst many well-educated people. Some people are lingual chameleons[1]: their language patterns completely change depending on their social surroundings. And many people are liguistic artistes[2] who choose their language to paint an image of themselves. However, failure is rife. [1] one Google result, different usage. [2] Sprachartisten

Dalewyn 4y ago

>confirm your cable is USB 4+ PD. I'm a tech nerd and wouldn't know WTF that means because USB is universally meaningless. Setting DIP switches is perfectly obvious, though. I miss the days messing with them and also jumpers.